SBC medical group is one of the largest cosmetic medicine clinic groups. We currently have 116 facilities in Japan, more than 400 doctors, and more than 3 million clients per year. We have several types of machines for body contouring, such as RF, diode laser, cryo, and so on. In 2021, 56,530 patients received non-surgical body contouring treatment. The number of facilities with Cryolipolysis was 51, and the number of patients who received Cryolipolysis was 29,283 per year. We have rules for reporting adverse events to our internal safety organization when they occur, and we manage them. I lectured about the prevention and management of complications of Cryolipolysis in body contouring treatment in IMCAS. With practitioner education, the severe adverse event’s rate for 2021 is currently less than half of the previous year’s rate.